Tg(CAG-Notch1)#Guiq
Transgene Detail

Summary

• Symbol: Tg(CAG-Notch1)#Guiq
• Name: transgene insertion, Guiquan Chen
• MGI ID: MGI:7311996
• Synonyms: CAG-LSL-N1ICD, LSL-N1ICD, NICD cTg
• Transgene: Tg(CAG-Notch1)#Guiq Location: unknown
• Alliance: Tg(CAG-Notch1)#Guiq page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene insertion comprises the following sequences flanked by insulator sequences: the CAG promoter, a loxP site flanked STOP cassette, sequence encoding amino acids of 1744 2531 (Notch1 intracellular domain; NICD) of mouse Notch1, and poly(A) signal sequences. The Notch1 sequence is only expressed after cre-mediated removal of the STOP cassette. (J:273599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:273599 Cheng S, et al., Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors. J Neurosci. 2019 Mar 20;39(12):2195-2207
• All: 3 reference(s)