Il10ra^tm1.1Flv
Targeted Allele Detail

Summary

• Symbol: Il10ra^tm1.1Flv
• Name: interleukin 10 receptor, alpha; targeted mutation 1.1, Richard A Flavell
• MGI ID: MGI:7311987
• Gene: Il10ra Location: Chr9:45165135-45180447 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Il10ra^tm1.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326428
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was floxed. Flp-mediated recombination removed the selection cassette. (J:326428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il10ra Mutation: 31 strains or lines available

References

• Original: J:326428 Yogev N, et al., CD4(+) T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. Cell Rep. 2022 Mar 29;38(13):110565
• All: 1 reference(s)