Jak2^em3Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Jak2^em3Gpt
• Name: Janus kinase 2; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
• MGI ID: MGI:7311786
• Synonyms: Jak2^em1Cflox
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^em3Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting generated a conditional allele. (J:326371)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 60 strains or lines available

References

• Original: J:326371 Mao Y, et al., Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. Mol Cell. 2022 Feb 3;82(3):527-541.e7
• All: 1 reference(s)