Tg(Thy1-CAST)12Rnix
Transgene Detail

Summary

• Symbol: Tg(Thy1-CAST)12Rnix
• Name: transgene insertion 12, Ralph A Nixon
• MGI ID: MGI:7311562
• Synonyms: hCAST Tg
• Transgene: Tg(Thy1-CAST)12Rnix Location: unknown
• Alliance: Tg(Thy1-CAST)12Rnix page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-CAST)12Rnix expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CAST (831)

  Cast	(MGI:1098236)

• Mutation details: The transgenic construct contains a mouse Thy1.1 (thymocyte differentiation antigen) promoter directing expression the human CAST (calpastatin) coding sequence. Founder line 12 expressed the highest amount of CAST protein (17 fold higher than controls). (J:142368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:142368 Rao MV, et al., Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. J Neurosci. 2008 Nov 19;28(47):12241-54
• All: 1 reference(s)