Foxo3^tm1.2Rdp
Targeted Allele Detail

Summary

• Symbol: Foxo3^tm1.2Rdp
• Name: forkhead box O3; targeted mutation 1.2, Ronald DePinho
• MGI ID: MGI:7310460
• Synonyms: FoxO3^L
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^tm1.2Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site, followed by an FRT-flanked neomycin resistance (neo) cassette upstream of exon 2, and a single loxP site downstream of exon 2. Flp-mediated recombination removed the neomycin cassette. (J:84269)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 51 strains or lines available

References

• Original: J:84269 Castrillon DH, et al., Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003 Jul 11;301(5630):215-8
• All: 4 reference(s)