Tigit^{em2(TIGIT)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tigit^{em2(TIGIT)Gpt}
• Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• MGI ID: MGI:7307471
• Synonyms: Tigit^{em1Cin(hTIGIT)}
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^{em2(TIGIT)Gpt} page

Mutation origin

• Strain of Origin: BALB/cJGpt

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Tigit^{em2(TIGIT)Gpt} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TIGIT (201633)

  Tigit

  (MGI:3642260)

• Mutation details: CRISPR-targeting replaced the endogenous sequence for the extracellular domain with the corresponding sequence from the human gene producing a fusion protein. (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 15 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)