Sirpa^{em2(SIRPA)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sirpa^{em2(SIRPA)Gpt}
• Name: signal-regulatory protein alpha; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• MGI ID: MGI:7306125
• Synonyms: Sirpa^{em1Cin(hSIRPa)}
• Gene: Sirpa Location: Chr2:129434755-129474148 bp, + strand Genetic Position: Chr2, 63.19 cM, cytoband F3
• Alliance: Sirpa^{em2(SIRPA)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Sirpa^{em2(SIRPA)Gpt} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SIRPA (140885)

  Sirpa

  (MGI:108563)

• Mutation details: CRISPR-targeting replaced the endogenous sequence for the extracellular domain with the corresponding sequence from the human gene producing a fusion protein. (J:293217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirpa Mutation: 50 strains or lines available

References

• Original: J:293217 GemPharmatech, GemPharmatech Website. 2020
• All: 1 reference(s)