Pptc7^em5Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pptc7^em5Gpt
• Name: PTC7 protein phosphatase homolog; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
• MGI ID: MGI:7304644
• Synonyms: Pptc7^em5Cd6386
• Gene: Pptc7 Location: Chr5:122422461-122462344 bp, + strand Genetic Position: Chr5, 62.28 cM
• Alliance: Pptc7^em5Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting introduced a coding region modification (del6386). (J:293217, J:362389)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

50 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pptc7 Mutation: 46 strains or lines available

References

• Original: J:362389 Xu X, et al., PPTC7 acts as an essential co-factor of the SCF(FBXL4) ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy. Cell Death Dis. 2025 Mar 1;16(1):145
• All: 2 reference(s)