Mettl3^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl3^em1Gpt
• Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7302185
• Synonyms: Mettl3^em1Cflox, METTL3^Flox
• Gene: Mettl3 Location: Chr14:52532298-52542585 bp, - strand Genetic Position: Chr14, 26.88 cM, cytoband C1
• Alliance: Mettl3^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting produced a floxed allele. (J:326758)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl3 Mutation: 45 strains or lines available

References

• Original: J:326758 Wang JN, et al., Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms. Sci Transl Med. 2022 Apr 13;14(640):eabk2709
• All: 3 reference(s)