Hmgcs2^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hmgcs2^em1Gpt
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7300309
• Synonyms: Hmgcs2^em1Cflox, Hmgcs2^fl
• Gene: Hmgcs2 Location: Chr3:98187751-98218054 bp, + strand Genetic Position: Chr3, 42.74 cM
• Alliance: Hmgcs2^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting inserted loxp sites into intron 12 and intron 23. (J:336417)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgcs2 Mutation: 36 strains or lines available

References

• Original: J:336417 Chong D, et al., Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
• All: 1 reference(s)