Ptpn20^em1Mmsk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptpn20^em1Mmsk
• Name: protein tyrosine phosphatase, non-receptor type 20; endonuclease-mediated mutation 1, Masakazu Miyajima
• MGI ID: MGI:7294472
• Gene: Ptpn20 Location: Chr14:33311164-33362711 bp, + strand Genetic Position: Chr14, 20.51 cM
• Alliance: Ptpn20^em1Mmsk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 4 deleted 104 bp. Western blot analysis confirmed the absence of protein expression in the choroid plexus. (J:326016)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn20 Mutation: 30 strains or lines available

References

• Original: J:326016 Xu H, et al., Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. Fluids Barriers CNS. 2022 Jun 3;19(1):39
• All: 1 reference(s)