Prss55^em1Huizh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prss55^em1Huizh
• Name: serine protease 55; endonuclease-mediated mutation 1, Hui Zhu
• MGI ID: MGI:7294425
• Synonyms: Prss55^-
• Gene: Prss55 Location: Chr14:64312887-64327611 bp, - strand Genetic Position: Chr14, 33.35 cM
• Alliance: Prss55^em1Huizh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 53 bp deletion in exon 3 (which is common to all predicted transcripts). Immunofluorescence assays confirmed absence of protein expression in the testis and epididymis. (J:307639)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss55 Mutation: 18 strains or lines available

References

• Original: J:307639 Zhu F, et al., PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice. J Cell Mol Med. 2021 Feb;25(4):2040-2051
• All: 1 reference(s)