Mapt^{em2(MAPT)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mapt^{em2(MAPT)Smoc}
• Name: microtubule-associated protein tau; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7290976
• Synonyms: Mapt^{em2(hMAPT)Smoc}
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{em2(MAPT)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mapt^{em2(MAPT)Smoc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The endogenous mouse Mapt gene was replaced by human MAPT gene via CRISPR gene editing techology. While hMAPT(Stock No.NM-HU-200116) mice function similarly to hMAPT(2) mice,for more detailed information please contact our technical advisor. (J:238766)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 428 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)