Ighd^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ighd^em1Smoc
• Name: immunoglobulin heavy constant delta; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7290369
• Gene: Ighd Location: Chr12:113371155-113379944 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighd^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1-6 of Ighm and exon 1-5 of Ighd gene was deleted to generate Ighm and Ighd knockout mice. Homozygous mutant mice lack mature B cells. It may be useful as a model for B cell immunodeficiency found in humans. (J:238766)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ighd Mutation: 19 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)