Gt(ROSA)26Sorem54(APOE-CYP3A4)Smoc
Endonuclease-mediated Allele Detail
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Symbol: |
Gt(ROSA)26Sorem54(APOE-CYP3A4)Smoc |
Name: |
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 54, Shanghai Model Organisms Center |
MGI ID: |
MGI:7290063 |
Synonyms: |
Gt(ROSA)26Sorem1(Liver-CYP3A4)Smoc |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sorem54(APOE-CYP3A4)Smoc page
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Allele Type: |
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Endonuclease-mediated (Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sorem54(APOE-CYP3A4)Smoc expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CYP3A4 (1576) |
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Mutation details: This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 Humanized sequence model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.
(J:238766)
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Inheritance: |
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Not Specified |
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
945 strains or lines available
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Original: |
J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017; |
All: |
1 reference(s) |
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