Tfap2e^tm1Mos
Targeted Allele Detail

Summary

• Symbol: Tfap2e^tm1Mos
• Name: transcription factor AP-2, epsilon; targeted mutation 1, Markus Moser
• MGI ID: MGI:7287853
• Gene: Tfap2e Location: Chr4:126609799-126630033 bp, - strand Genetic Position: Chr4, 60.91 cM
• Alliance: Tfap2e^tm1Mos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317046
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin DNA construct containing a stop codon was inserted into the second exon of the gene. This results in a premature termination of the translation process and a complete absence of functional encoded protein in homozygous mice. (J:317046)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2e Mutation: 10 strains or lines available

References

• Original: J:317046 Niebler S, et al., Activating enhancer binding protein 2 epsilon (AP-2epsilon)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development. Arthritis Res Ther. 2015 May 12;17:119
• All: 1 reference(s)