Rab44^em1Gme
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rab44^em1Gme
• Name: RAB44, member RAS oncogene family; endonuclease-mediated mutation 1, Gael Menasche
• MGI ID: MGI:7287523
• Synonyms: KO^Rab44
• Gene: Rab44 Location: Chr17:29333119-29367954 bp, + strand Genetic Position: Chr17, 15.14 cM
• Alliance: Rab44^em1Gme page

Mutation origin

• Strain of Origin: C57BL/6JRj

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 4 bp deletion within exon 9 creating a premature stop codon 79 amino acid residues downstream of the deletion in the two transcriptional isoforms. Western blot analysis confirmed the absence of both the long and short isoforms. (J:325680)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab44 Mutation: 41 strains or lines available

References

• Original: J:325680 Longe C, et al., Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation. J Allergy Clin Immunol. 2022 Apr 22
• All: 1 reference(s)