Slc6a1^tm1.2Ntrch
Targeted Allele Detail

Summary

• Symbol: Slc6a1^tm1.2Ntrch
• Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1.2, Nicolas Tritsch
• MGI ID: MGI:7284723
• Synonyms: Gat1^KO
• Gene: Slc6a1 Location: Chr6:114259735-114294491 bp, + strand Genetic Position: Chr6, 53.05 cM, cytoband E3
• Alliance: Slc6a1^tm1.2Ntrch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP site, followed by an FRT-flanked neomycin resistance cassette, upstream of exon 2. A second loxP site is inserted downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette and cre-mediated recombination deleted exons 2 to 4. (J:325275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a1 Mutation: 48 strains or lines available

References

• Original: J:325275 Melani R, et al., Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake. Cell Rep. 2022 Apr 19;39(3):110716
• All: 1 reference(s)