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Bard1tm8.1Rjbr
Targeted Allele Detail
Summary
Symbol: Bard1tm8.1Rjbr
Name: BRCA1 associated RING domain 1; targeted mutation 8.1, Richard J Baer
MGI ID: MGI:7284161
Synonyms: Bard1-AAE
Gene: Bard1  Location: Chr1:71066694-71142300 bp, - strand  Genetic Position: Chr1, 35.67 cM
Alliance: Bard1tm8.1Rjbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  KV1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsThe targeting vector contains a loxP-flanked neomycin inserted into intron 3 and the following AAE amino acid substitutions - phenylalanine to alanine at position 125 (F125A, TTT to GCT), aspartic acid to alanine at position 127 (D127A, GAT to GCT), and alanine to glutamic acid at position 128 (A128E, GCA to GAA) - inserted into exon 4. The mutations correspond to human mutations (F133, D135, F136) that disrupt the interaction of BARD1 with Rad51 and impair the strand-invasion step of homologous recombination. Cre-mediated recombination removed the neo cassette. (J:94077)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bard1 Mutation:  55 strains or lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory