Rnps1^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnps1^em1Btlr
• Name: RNA binding protein with serine rich domain 1; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:7284061
• Synonyms: Rnsp1^F181I
• Gene: Rnps1 Location: Chr17:24633620-24644872 bp, + strand Genetic Position: Chr17, 12.39 cM, cytoband A3.3
• Alliance: Rnps1^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation that produces the amino acid substitution of phenylalnine with isoleucine at position 191 (F181I). (J:324854)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnps1 Mutation: 23 strains or lines available

References

• Original: J:324854 Zhong X, et al., RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2200128119
• All: 1 reference(s)