Ccnb1ip1^em1Amp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccnb1ip1^em1Amp
• Name: cyclin B1 interacting protein 1; endonuclease-mediated mutation 1, Alberto M Pendas
• MGI ID: MGI:7281856
• Synonyms: Hei10^-
• Gene: Ccnb1ip1 Location: Chr14:51026706-51033185 bp, - strand Genetic Position: Chr14, 26.25 cM
• Alliance: Ccnb1ip1^em1Amp page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 4 bp deletion (TTGC, GRCm39:51031159-51031162) in exon 2, leading to a frameshift and premature stop codon (p.Cys51Thrfs*8). (J:303558)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnb1ip1 Mutation: 21 strains or lines available

References

• Original: J:303558 Felipe-Medina N, et al., A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. Elife. 2020 Aug 26;9:e56996
• All: 1 reference(s)