Pabpn1^em1Atp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pabpn1^em1Atp
• Name: poly(A) binding protein, nuclear 1; endonuclease-mediated mutation 1, Andreas Trumpp
• MGI ID: MGI:7281149
• Synonyms: Pabpn1^flox
• Gene: Pabpn1 Location: Chr14:55131600-55136384 bp, + strand Genetic Position: Chr14, 27.98 cM
• Alliance: Pabpn1^em1Atp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 technology inserted loxP sites flanking exons 3 and 4. (J:324612)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pabpn1 Mutation: 12 strains or lines available

References

• Original: J:324612 Sommerkamp P, et al., CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells. Sci Rep. 2022 May 3;12(1):7181
• All: 1 reference(s)