Prl^{tm1.1(PRL)Rui}
Targeted Allele Detail

Summary

• Symbol: Prl^{tm1.1(PRL)Rui}
• Name: prolactin; targeted mutation 1.1, Hallgeir Rui
• MGI ID: MGI:7280900
• Gene: Prl Location: Chr13:27241553-27249187 bp, + strand Genetic Position: Chr13, 12.25 cM
• Alliance: Prl^{tm1.1(PRL)Rui} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324566
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Prl^{tm1.1(PRL)Rui} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRL (5617)

  Prl	(MGI:97762)

• Mutation details: The targeting vector is designed to replace exon 1 of the gene with the full-length human PRL coding sequence followed by a floxed neomycin cassette. Cre-mediated recombination removed the neo cassette. Immunoblot analysis indicates that mice do not express endogenous prolactin. (J:324566)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prl Mutation: 28 strains or lines available

References

• Original: J:324566 Sun Y, et al., NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers. Sci Adv. 2021 Sep 17;7(38):eabc8145
• All: 1 reference(s)