Tlr7^em1Anu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tlr7^em1Anu
• Name: toll-like receptor 7; endonuclease-mediated mutation 1, The Australian National University
• MGI ID: MGI:7280775
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^em1Anu page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1 bp deletion (G at position 784) leading to a premature stop codon at amino acid 276. (J:324448)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 23 strains or lines available

References

• Original: J:324448 Brown GJ, et al., TLR7 gain-of-function genetic variation causes human lupus. Nature. 2022;605(7909):349-356
• All: 1 reference(s)