Pou2f3^em1Cbwi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pou2f3^em1Cbwi
• Name: POU domain, class 2, transcription factor 3; endonuclease-mediated mutation 1, Craig Wilen
• MGI ID: MGI:7280718
• Gene: Pou2f3 Location: Chr9:43035222-43117052 bp, - strand Genetic Position: Chr9, 24.21 cM
• Alliance: Pou2f3^em1Cbwi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: : CRISPR/cas9 endonuclease-mediated genome editing was used to delete 8 bp (ATGCCACCTGAG replaced with TCTC) from exon 4. (J:315001)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou2f3 Mutation: 36 strains or lines available

References

• Original: J:315001 Walker FC, et al., Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. PLoS Pathog. 2021 Mar;17(3):e1009402
• All: 6 reference(s)