Podn^tm1Pklt
Targeted Allele Detail

Summary

• Symbol: Podn^tm1Pklt
• Name: podocan; targeted mutation 1, Paul E Klotman
• MGI ID: MGI:7280712
• Synonyms: podocan^-
• Gene: Podn Location: Chr4:107871988-107889534 bp, - strand Genetic Position: Chr4, 50.18 cM
• Alliance: Podn^tm1Pklt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector is designed to replace exons 4-8 of the gene with a neomycin resistance (neo) cassette. (J:324505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Podn Mutation: 36 strains or lines available

References

• Original: J:324505 Hutter R, et al., Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. Circulation. 2013 Nov 26;128(22):2351-63
• All: 1 reference(s)