Ptger4^tm2.1Bhk
Targeted Allele Detail

Summary

• Symbol: Ptger4^tm2.1Bhk
• Name: prostaglandin E receptor 4 (subtype EP4); targeted mutation 2.1, Beverly H Koller
• MGI ID: MGI:7279302
• Synonyms: Ptger4^flox, Ptger4^floxed
• Gene: Ptger4 Location: Chr15:5262880-5273668 bp, - strand Genetic Position: Chr15, 1.99 cM
• Alliance: Ptger4^tm2.1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317897
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2. An adjacent frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:317897)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger4 Mutation: 33 strains or lines available

References

• Original: J:317897 Gruzdev A, et al., PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth. Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):109-19
• All: 2 reference(s)