Tm6sf2^em1Luoj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tm6sf2^em1Luoj
• Name: transmembrane 6 superfamily member 2; endonuclease-mediated mutation 1, Jie Luo
• MGI ID: MGI:7276258
• Gene: Tm6sf2 Location: Chr8:70525574-70532716 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Tm6sf2^em1Luoj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Single point mutation
• Mutation details: TALEN technology was used to introduce a 1 bp deletion (67delC) in exon 1 that causes an L23 frameshift mutation. (J:296036)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm6sf2 Mutation: 37 strains or lines available

References

• Original: J:296036 Li BT, et al., Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease. PLoS Genet. 2020 Aug;16(8):e1008955
• All: 1 reference(s)