Kras^em4Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kras^em4Smoc
• Name: Kirsten rat sarcoma viral oncogene homolog; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
• MGI ID: MGI:7265096
• Synonyms: Kras^{em4(LSL-G12D)Smoc}
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^em4Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced by loxP-STOP-loxP cassette and an exon 2 containing the oncogenic p.G12D mutation. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development. (J:238766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 76 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 4 reference(s)