Tg(ACTA-FOXO1)A1Ose
Transgene Detail

Summary

• Symbol: Tg(ACTA-FOXO1)A1Ose
• Name: transgene insertion A1, Osamu Ezaki
• MGI ID: MGI:7264942
• Transgene: Tg(ACTA-FOXO1)A1Ose Location: unknown
• Alliance: Tg(ACTA-FOXO1)A1Ose page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA-FOXO1)A1Ose expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FOXO1 (2308)

  Foxo1

  (MGI:1890077)

  Expresses a human FOXO1 cDNA.

• Mutation details: A human skeletal muscle actin promoter was used to drive expression of a human FOXO1 cDNA, including exon 1 and the intron of the human skeletal muscle alpha actin gene as well as the bovine growth hormone polyadenylation site. (J:93334)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93334 Kamei Y, et al., Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem. 2004 Oct 24;279(39):41114-23
• All: 6 reference(s)