Adar^em1Kawy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adar^em1Kawy
• Name: adenosine deaminase, RNA-specific; endonuclease-mediated mutation 1, Yukio Kawahara
• MGI ID: MGI:7264427
• Synonyms: Adar1^W197A
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^em1Kawy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination using a single-stranded donor RNA with 2 GCC mutations was used to insert a W197A mutation. The second set of targeted nucleotides did not insert in this allele. This allele was created in embryos from mice homozygous for Ifih1^tm1Aki. This mutation reduces RNA editing activity. (J:323650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 83 strains or lines available

References

• Original: J:323650 Nakahama T, et al., Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutieres-syndrome-like encephalopathy. Immunity. 2021 Sep 14;54(9):1976-1988.e7
• All: 2 reference(s)