Tg(TcraM38,TcrbM38)329Biat
Transgene Detail

Summary

• Symbol: Tg(TcraM38,TcrbM38)329Biat
• Name: transgene insertion 329, Biomodels Austria
• MGI ID: MGI:7263362
• Synonyms: M38 TCR-transgenic, Maxi, Tg(Tcra,Tcrb)329Biat
• Transgene: Tg(TcraM38,TcrbM38)329Biat Location: unknown
• Alliance: Tg(TcraM38,TcrbM38)329Biat page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraM38,TcrbM38)329Biat expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)	Expresses a Tcra clone specific for the M38-derived epitope of MCMV
  mouse	Tcrb (MGI:98578)	Expresses a Tcrb clone specific for the M38-derived epitope of MCMV

• Mutation details: This transgene expresses a Tcra and Tcrb clone specific for the M38-derived epitope of MCMV. The "Maxi" mouse is transgenic for the rearranged M38 hybridoma Tcra and Tcrb chains, resulting in a percentage of M38-specific CD8 T cells among total nave CD8 T cells of around 90%. (J:183174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:183174 Torti N, et al., Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. PLoS Pathog. 2011 Oct;7(10):e1002313
• All: 12 reference(s)