Fermt3^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fermt3^em1Smoc
• Name: fermitin family member 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7263276
• Synonyms: Fermt3^{em1(flox)Smoc}
• Gene: Fermt3 Location: Chr19:6976326-6996837 bp, - strand Genetic Position: Chr19, 5.13 cM
• Alliance: Fermt3^em1Smoc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The exon 2 of the Fermt3 (Kindlin3) gene was replaced by a fragment containing mouse WT exon 2 sequences flanked with loxP sites on both sides. A neomycin cassette was inserted into intron 2. Neo-positive ES cells were selected for generation of Fermt3 (Kindlin3)-floxed mouse strain. (J:287711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fermt3 Mutation: 31 strains or lines available

References

• Original: J:287711 Meller J, et al., Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages. JCI Insight. 2017 Jun 2;2(11)
• All: 3 reference(s)