Acox2^em1Jynz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acox2^em1Jynz
• Name: acyl-Coenzyme A oxidase 2, branched chain; endonuclease-mediated mutation 1, Jian-Yuan Zhao
• MGI ID: MGI:7263204
• Gene: Acox2 Location: Chr14:14210420-14244262 bp, + strand Genetic Position: Chr14, 4.77 cM, cytoband A1
• Alliance: Acox2^em1Jynz page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a deletion of 15146bp spanning exon 3 to exon 13. (J:323193)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acox2 Mutation: 40 strains or lines available

References

• Original: J:323193 Zhang Y, et al., Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Cell Death Dis. 2022 Mar 29;13(3):279
• All: 1 reference(s)