Stab2^em1Mae
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stab2^em1Mae
• Name: stabilin 2; endonuclease-mediated mutation 1, Nobuyo Maeda
• MGI ID: MGI:7263169
• Synonyms: Stab2^-
• Gene: Stab2 Location: Chr10:86677062-86843889 bp, - strand Genetic Position: Chr10, 43.14 cM
• Alliance: Stab2^em1Mae page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intragenic deletion, Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a 1bp deletion and a glycine to aspartate substitution at amino acid 864 (G864D). Western blot analysis confirmed the absence of protein due to the 1bp deletion. (J:323262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stab2 Mutation: 140 strains or lines available

References

• Original: J:323262 Kayashima Y, et al., Reduction of Stabilin-2 Contributes to a Protection Against Atherosclerosis. Front Cardiovasc Med. 2022;9:818662
• All: 1 reference(s)