Nedd4l^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nedd4l^em1Smoc
• Name: neural precursor cell expressed, developmentally down-regulated gene 4-like; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7262907
• Synonyms: Nedd4-2^-
• Gene: Nedd4l Location: Chr18:65020776-65350899 bp, + strand Genetic Position: Chr18, 37.57 cM, cytoband E1
• Alliance: Nedd4l^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology was used to delete exon 8. (J:323315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nedd4l Mutation: 75 strains or lines available

References

• Original: J:323315 Liu X, et al., Nedd4-2 haploinsufficiency in mice causes increased seizure susceptibility and impaired Kir4.1 ubiquitination. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166128
• All: 3 reference(s)