Havcr2^em1Lkane
Endonuclease-mediated Allele Detail

Summary

• Symbol: Havcr2^em1Lkane
• Name: hepatitis A virus cellular receptor 2; endonuclease-mediated mutation 1, Lawrence P Kane
• MGI ID: MGI:7262886
• Synonyms: Tim-3^fl
• Gene: Havcr2 Location: Chr11:46345762-46372082 bp, + strand Genetic Position: Chr11, 27.9 cM
• Alliance: Havcr2^em1Lkane page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR/cas9 endonuclease-mediated genome editing is used to insert loxP sites flanking exon 4. (J:321210)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Havcr2 Mutation: 30 strains or lines available

References

• Original: J:321210 Banerjee H, et al., Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment. Cell Rep. 2021 Sep 14;36(11):109699
• All: 2 reference(s)