Gt(ROSA)26Sor^tm1Lkane
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Lkane
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Lawrence P Kane
• MGI ID: MGI:7262883
• Synonyms: FSF-Tim3
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Lkane page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258877
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1Lkane expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Havcr2 (MGI:2159682)	Flag-tagged

• Mutation details: The targeting construct contains a loxP-flanked STOP cassette and a full length murine FLAG tagged Hacvr2 cDNA sequence. This entire construct was inserted into the Gt(ROSA)26Sor locus. (J:258877)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 945 strains or lines available

References

• Original: J:258877 Avery L, et al., Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2455-2460
• All: 4 reference(s)