Hlfem1(cre/ERT2)Smoc
Endonuclease-mediated Allele Detail
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Symbol: |
Hlfem1(cre/ERT2)Smoc |
Name: |
hepatic leukemia factor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
MGI ID: |
MGI:7262729 |
Synonyms: |
HlfCreER |
Gene: |
Hlf Location: Chr11:90227362-90281721 bp, - strand Genetic Position: Chr11, 55.03 cM
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Alliance: |
Hlfem1(cre/ERT2)Smoc page
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Allele Type: |
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Endonuclease-mediated (Conditional ready, Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Hlfem1(cre/ERT2)Smoc expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Hlf (MGI:96108) |
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Mutation details: CRISPR/Cas9 genome editing technology was used to insert a 2A-Cre and rox flanked ERT2 expression cassette into the exon 4 and 3' UTR of the Hlf gene.
(J:312489)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Hlf
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hlf Mutation: |
15 strains or lines available
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Original: |
J:312489 Tang W, et al., Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate. Front Cell Dev Biol. 2021;9:728057 |
All: |
1 reference(s) |
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