Phf6^tm1.1Aafo
Targeted Allele Detail

Summary

• Symbol: Phf6^tm1.1Aafo
• Name: PHD finger protein 6; targeted mutation 1.1, Adolfo A Ferrando
• MGI ID: MGI:7261438
• Synonyms: Phf6^f
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^tm1.1Aafo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273223
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 4 and an FRT- and loxP-flanked neomycin resistance cassette downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 4 and 5 floxed. (J:273223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:273223 Wendorff AA, et al., Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL. Cancer Discov. 2019 Mar;9(3):436-451
• All: 4 reference(s)