Mlkl^em2Hbz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em2Hbz
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 2, Haibing Zhang
• MGI ID: MGI:7261369
• Synonyms: Mlkl^-, Mlkl(137bp ins)
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em2Hbz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: A 137 bp sequence was inserted between Chr8:112060243-112060244 (GRCm39) in the coding region of exon 2 through CRISPR/Cas9 technology. (J:238962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:238962 Zhang X, et al., MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome. Cell Rep. 2016 Sep 20;16(12):3247-59
• All: 1 reference(s)