Kdm3b^tm1.1Mtac
Targeted Allele Detail

Summary

• Symbol: Kdm3b^tm1.1Mtac
• Name: KDM3B lysine (K)-specific demethylase 3B; targeted mutation 1.1, Makoto Tachibana
• MGI ID: MGI:7261363
• Synonyms: Jmjd1b^Flag-KI
• Gene: Kdm3b Location: Chr18:34910100-34971713 bp, + strand Genetic Position: Chr18, 18.73 cM, cytoband B3
• Alliance: Kdm3b^tm1.1Mtac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286480
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: The targeting vector inserted a triple FLAG epitope tag at the STOP codon. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the STOP codon. (J:286480)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm3b Mutation: 139 strains or lines available

References

• Original: J:286480 Kuroki S, et al., Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis. Stem Cell Reports. 2018 Apr 10;10(4):1340-1354
• All: 2 reference(s)