Ggct^em1.1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ggct^em1.1Smoc
• Name: gamma-glutamyl cyclotransferase; endonuclease-mediated mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:7261322
• Synonyms: GGCT^Flox, Ggct^tm1.1Smoc
• Gene: Ggct Location: Chr6:54962080-54969947 bp, - strand Genetic Position: Chr6, 27.26 cM
• Alliance: Ggct^em1.1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a loxP site upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:317466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggct Mutation: 10 strains or lines available

References

• Original: J:317466 He Z, et al., Ras Downstream Effector GGCT Alleviates Oncogenic Stress. iScience. 2019 Sep 27;19:256-266
• All: 1 reference(s)