Acsl4^tm1.1Asg
Targeted Allele Detail

Summary

• Symbol: Acsl4^tm1.1Asg
• Name: acyl-CoA synthetase long-chain family member 4; targeted mutation 1.1, Andrew S Greenberg
• MGI ID: MGI:7261309
• Synonyms: Acsl4^flox
• Gene: Acsl4 Location: ChrX:141100989-141173531 bp, - strand Genetic Position: ChrX, 63.12 cM
• Alliance: Acsl4^tm1.1Asg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290102
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exons 3 and 4 and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:290102)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsl4 Mutation: 16 strains or lines available

References

• Original: J:290102 Killion EA, et al., A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Mol Metab. 2018 Mar;9:43-56
• All: 4 reference(s)