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Aqp4tm1Gghu
Targeted Allele Detail
Summary
Symbol: Aqp4tm1Gghu
Name: aquaporin 4; targeted mutation 1, Gang Hu
MGI ID: MGI:7261160
Synonyms: AQP4-
Gene: Aqp4  Location: Chr18:15522553-15544039 bp, - strand  Genetic Position: Chr18, 8.74 cM
Alliance: Aqp4tm1Gghu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112451
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced part of the exon 1 coding sequence. (J:112451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp4 Mutation:  42 strains or lines available
References
Original:  J:112451 Fan Y, et al., Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice. J Neurosci Res. 2005 Nov 15;82(4):458-64
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory