Itgb8^tm1Jhmc
Targeted Allele Detail

Summary

• Symbol: Itgb8^tm1Jhmc
• Name: integrin beta 8; targeted mutation 1, Joseph H McCarty
• MGI ID: MGI:7260206
• Synonyms: beta8-ConKi
• Gene: Itgb8 Location: Chr12:119121757-119202537 bp, - strand Genetic Position: Chr12, 63.48 cM
• Alliance: Itgb8^tm1Jhmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321982
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A conditional knock-in allele was generated by insertion of a premature STOP codon within one of the exons coding for the cytoplasmic domain of Itgb8 integrin and a floxed cDNA (mini-gene) upstream. (J:321982)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb8 Mutation: 45 strains or lines available

References

• Original: J:321982 De A, et al., The beta8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. Development. 2022 Mar 15;149(6):dev200472
• All: 1 reference(s)