Hlcs^tm1Jze
Targeted Allele Detail

Summary

• Symbol: Hlcs^tm1Jze
• Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase); targeted mutation 1, Janos Zempleni
• MGI ID: MGI:7260197
• Gene: Hlcs Location: Chr16:93929741-94114430 bp, - strand Genetic Position: Chr16, 55.12 cM, cytoband C4
• Alliance: Hlcs^tm1Jze page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322810
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 8 and a second loxP site, followed by an FRT-flanked neomycin resistance (neo) cassette, downstream of exon 8. (J:322810)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hlcs Mutation: 43 strains or lines available

References

• Original: J:322810 Sadri M, et al., Holocarboxylase synthetase knockout is embryonic lethal in mice. PLoS One. 2022;17(4):e0265539
• All: 1 reference(s)