Tm6sf2^em1Ddsn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tm6sf2^em1Ddsn
• Name: transmembrane 6 superfamily member 2; endonuclease-mediated mutation 1, Nicholas O Davidson
• MGI ID: MGI:7259918
• Synonyms: Tm6-flox
• Gene: Tm6sf2 Location: Chr8:70525574-70532716 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Tm6sf2^em1Ddsn page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted loxP sites flanking exon 2. Two lines were established, however data is presented for only one line, represented by this record. (J:322313)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm6sf2 Mutation: 33 strains or lines available

References

• Original: J:322313 Newberry EP, et al., Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer. Hepatology. 2021 Sep;74(3):1203-1219
• All: 1 reference(s)