Spp1^em1Msasn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Spp1^em1Msasn
• Name: secreted phosphoprotein 1; endonuclease-mediated mutation 1, Micheal Sasner
• MGI ID: MGI:7259872
• Synonyms: Spp1-IRES-tdTomato, Spp1^Tdt, Spp1
• Gene: Spp1 Location: Chr5:104582984-104588916 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Spp1^em1Msasn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 endonuclease-mediated genome editing is used to insert an IRES-tdTomato-bGH poly(A) signal past the stop codon in exon 7. (J:322668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spp1 Mutation: 45 strains or lines available

References

• Original: J:322668 De Schepper S, et al., Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimer's Disease Models. bioRxiv. 2022
• All: 3 reference(s)