Pycard^em2Jhan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pycard^em2Jhan
• Name: PYD and CARD domain containing; endonuclease-mediated mutation 2, Jiahuai Han
• MGI ID: MGI:7258407
• Synonyms: Asc^-
• Gene: Pycard Location: Chr7:127590545-127593039 bp, - strand Genetic Position: Chr7, 69.88 cM, cytoband F4
• Alliance: Pycard^em2Jhan page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 111 bp insertion (GCAGATGGACGCCATAGATCTCACTGACAAACTTGTCAGCTACTATCTGGAGTCGTATGCTTGGAGCTCACAATGACTGTGCTTAGAGACATGGGCTTACAGGAGCTGGCT) + 121 bp deletion (CCTGTAAGCCCATGTCTCTAAG..TGCAGCAGGGCCCCGCGTGG) knockout allele was created using an sgRNA (targeting TATGGGCGCATCCCACGCG) with CRISPR/Cas9 technology. (J:309361)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycard Mutation: 16 strains or lines available

References

• Original: J:309361 Zhang Y, et al., A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5. PLoS Biol. 2021 Aug;19(8):e3001304
• All: 1 reference(s)